Nephroprotective Activity of Some Indigenous Medicinal Plants in Cisplatin Induced Nephrotoxicity

Aim: The aim of the present investigation is to study nephroprotective activity two indigenous medicinal plants. Material and methods: Dried leaves Alstonia scholaris Centella asiatica were procured from garden campus Pharmacy College in month September, Bhopal, Madhya Pradesh, India. Around 500 gm dried coarsely powdered weighed filled Soxhlet apparatus for extraction. Wistar albino rats either sex between 2 3 months age weighing 150-200 used which central animal house. acute oral toxicity studies carried out according guidelines set by Organization Economic Co-operation Development (OECD), revised draft guideline 423. Cisplatin (5mg/kg, i.p) was administered rats. conducted 15 days divided into 12 groups (n=6). Rsults: Among all extracts asiatica, methanolic extract showed a significant effect (P>0.01) as compared other extracts. This shows that at these doses 200 400 mg/kg have preventive protective potential against renal toxicity, suggesting it role. scholaris, dichloromethane most highly (P>0.001) Methanolic also extract. Petroleum ether almost negligible effect. Conclusion: results obtained this shown displayed both chronic conditions. Besides obvious therapeutic importance, components would be useful understanding mechanism diseases with higher levels cellular molecular level.